期刊论文详细信息
Journal of Thoracic Disease
Codeine prescription pattern and treatment responses in patients with chronic cough: a routinely collected institutional database analysis
article
Ji-Yoon Oh1  Yu Ri Kang1  Jin An2  Eugene Choo3  Ji-Hyang Lee1  Hyouk-Soo Kwon1  Jae-Seung Lee4  Sei Won Lee4  Tae-Bum Kim1  Yeon-Mok Oh4  You Sook Cho1  Sang-Do Lee4  Woo-Jung Song1 
[1] Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine;Department of Pulmonary, Allergy and Critical Care Medicine, College of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University;Division of Allergy and Immunology, Mount Sinai School of Medicine;Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine
关键词: Codeine;    cough;    antitussive;    real-world evidence;    routinely collected data;   
DOI  :  10.21037/jtd-22-1857
学科分类:呼吸医学
来源: Pioneer Bioscience Publishing Company
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【 摘 要 】

Background: Codeine has been long used as an antitussive drug in several countries. However, a prescription pattern of codeine, such as dose or treatment duration, has not been reported in detail. Furthermore, there is few scientific evidence on the efficacy and safety. We aimed to examine codeine prescription pattern and explore treatment response in patients with chronic cough in real-world practice. Methods: This was a retrospective cohort analysis of patients with chronic cough who were newly referred to tertiary allergy and asthma clinics between July 2017 and July 2018. Routinely collected electronic healthcare records (EHRs), including medical notes, prescriptions, and outpatient visits, were analyzed. Codeine prescription records were examined for duration, mean daily dose, and 1-year cumulative dose. Codeine responses were evaluated by manual EHR reviews. Results: 8 weeks; they were older and had a longer cough duration, throat abnormal sensation and less dyspnea than patients prescribed codeine for ≤8 weeks or who did not receive codeine. Codeine prescription and duration was positively associated with the number of other cough-related medications, diagnostic tests, or outpatient visits. Cough status change was noted in 61.3% of codeine-prescribed patients (as ‘improved’ in 40.1% and ‘not improved’ in 21.2%), but not documented in 38.7%. Side effects were described in 7.8%. Conclusions: Codeine prescription may be frequent and chronic in real-world practice of patients with chronic cough, despite the lack of robust clinical evidence on the efficacy. High prescription rates suggest unmet clinical needs. Prospective studies are warranted to identify codeine treatment responses and safety, and to build up clinical evidence to guide appropriate use of narcotic antitussives.

【 授权许可】

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