Pre-implant left ventricular dimension is not associated with worse outcomes after left ventricular assist device implantation

Journal of Thoracic Disease

article

Amudan J. Srinivasan¹  Mahbub Jamil²  Laura Seese²  Ibrahim Sultan²  Gavin Hickey³  Mary E. Keebler³  Michael A. Mathier³  Arman Kilic² 

[1] Department of Surgery, University of Pittsburgh Medical Center;Division of Cardiac Surgery, University of Pittsburgh Medical Center;Heart and Vascular Institute, University of Pittsburgh Medical Center

关键词: Left ventricular end-diastolic diameter (LVEDD);    ventricular assist device;    mechanical circulatory support;    advanced heart failure;   

DOI  :  10.21037/jtd-20-2778

学科分类：呼吸医学

来源: Pioneer Bioscience Publishing Company

【 摘 要 】

Background: Left ventricular dimension has the potential to impact clinical outcomes following implantation of left ventricular assist devices (LVAD). We investigated the effect of pre-implant left ventricular end-diastolic diameter (LVEDD) on outcomes following LVAD implantation. Methods: Patients implanted with a continuous-flow LVAD between 2004 and 2018 at a single institution were included. The primary outcome was death while on LVAD support. Secondary outcomes included adverse event rates such as renal failure requiring dialysis, device thrombosis, and right ventricular failure. The LVEDD measurements were dichotomized using restricted cubic splines and threshold regression. Survival was determined using Kaplan-Meier estimates. Multivariable logistic regression was used to determine risk-adjusted mortality based on LVEDD. Results: A total of 344 patients underwent implantation of a continuous flow LVAD during the study period. The optimal cut point for LVEDD was 65 mm, with 126 (36.6%) subjects in the 65 mm group. The LVEDD <65 mm group was older, had more females, higher incidence of diabetes, more pre-implant mechanical ventilation, and more admissions for acute myocardial infarctions (all, P0.05). Risk-adjusted survival at 1-year (OR 1.3, 95% CI: 0.6–2.5, P=0.53) was also comparable between the groups. Furthermore, incremental increases in LVEDD when modeled as a continuous variable did not impact overall mortality (OR 0.98, 95% CI: 0.9–1.0, P=0.09). Conclusions: Preoperative LVEDD was not associated with rates of major morbidities or mortality following LVAD implantation.

【 授权许可】

Unknown