Low CD4 T cell count predicts radiological progression in severe and critically ill COVID-19 patients: a case control study

Journal of Thoracic Disease

article

Qingqing Wang¹  Yumeng Yao¹  Zheyong Huang²  Jiatian Cao²  Chouwen Zhu³  Kaihuan Yu⁴  Jue Pan¹  Bijie Hu¹ 

[1] Department of Infectious Diseases, Zhongshan Hospital, Fudan University;Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University;Department of Gastroenterology, Zhongshan Hospital, Fudan University;Department of Hepatobiliary Endoscopic Surgery, Renmin Hospital, Wuhan University

关键词: Novel coronavirus disease (COVID-19);    predictive factors;    CD4 T cells;    radiological progression;   

DOI  :  10.21037/jtd-20-1848

学科分类：呼吸医学

来源: Pioneer Bioscience Publishing Company

【 摘 要 】

Background: Novel coronavirus disease (COVID-19) has spread globally and caused over 3 million deaths, posing great challenge on public health and medical systems. Limited data are available predictive factors for disease progression. We aim to assess clinical and radiological predictors for pulmonary aggravation in severe and critically ill COVID-19 patients. Methods: Patients with confirmed COVID-19 in Renmin Hospital of Wuhan University, China, between Feb. 6th, 2020 and Feb. 21st, 2020 were retrospectively collected. Enrolled patients were divided into non-progression group and progression group based on initial and follow-up chest CTs. Clinical, laboratory, and radiological variables were analyzed. Results: 38 °C (P=0.002), lower platelet count (P=0.011), lower CD4 T cell count (P=0.002), lower CD8 count (P=0.011), higher creatine kinase level (P=0.002), and lower glomerular filtration rate (P=0.018). On both univariate and multivariable analysis, only CD4 T cell count <200/µL was significant (OR, 6.804; 95% CI, 1.450–31.934; P=0.015) for predicting pulmonary progression. Conclusions: Low CD4 T cell count predicts progression of pulmonary change in severe and critically ill patients with COVID-19.

【 授权许可】

Unknown