期刊论文详细信息
Journal of Gastrointestinal Oncology
Network and pathway-based analysis of candidate genes associated with esophageal adenocarcinoma
article
Junfeng Li1  Ling Peng2  Hanbing Li3  Yan Cai1  Peng Yao1  Qin Chen1  Xiaolei Li1  Qiuxi Zhou2 
[1] Department of Thoracic Surgery, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College;Department of General Internal Medicine, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital Affiliated to University of Electronic Science and Technology of China;Department of Thyroid and Breast Surgery, Affiliated Hospital of North Sichuan Medical College
关键词: Esophageal adenocarcinoma;    oncogene;    function enrichment analysis;    pathway crosstalk;    protein-protein interaction network;   
DOI  :  10.21037/jgo-22-1286
学科分类:肿瘤学
来源: Pioneer Bioscience Publishing Company
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【 摘 要 】

Background: Previous studies have made some headway in analyzing esophageal adenocarcinoma (EA) with respect to pathogenic factors, treatment methods, and prognosis. However, far less is known about the molecular mechanisms. Thus, a comprehensive analysis focusing on the biological function and interaction of EA genes would provide valuable information for understanding the pathogenesis of EA, which may provide new insights into gene function as well as potential therapy targets. Methods: We selected 109 genes related to EA by reviewing 458 publications from the PubMed database. In addition, performing gene enrichment assays, pathway enrichment assays, pathway crosstalk analysis, and extraction of EA-specific subnetwork were used to describe the relevant biochemical processes. Results: Function analysis revealed that biological processes and biochemical pathways associated with apoptotic and metabolic processes, a variety of cancers, and drug reaction pathways. Further, 12 novel genes (PTHLH, SUMO2, TYMS, APP, PTGIR, SP1, UBC, COL1A1, GSTO1, TRAF6, BMP7, and RAB40B) were identified in the EA-specific network, which might provide helpful information for clinical application. Conclusions: Overall, by integrating pathways and networks to explore the pathogenetic mechanisms underlying EA, our results could significantly improve our understanding of the molecular mechanisms of EA and form a basis for selection of potential molecular targets for further exploration.

【 授权许可】

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