Association of sleep duration, sleep apnea, and shift work with risk of colorectal neoplasms: a systematic review and meta-analysis

Journal of Gastrointestinal Oncology

article

Gang Wang¹  Jian-Jiang Wang³  Chao-Huang Lin²  Qing Zhou²  Wei-Long Wang²  Tao Qin²  Xin Li³  Ze-Jun Wang¹ 

[1] Department of Gastrointestinal Surgery, the Affiliated Hospital of Guizhou Medical University;Department of Gastrointestinal surgery, the Affiliated Cancer Hospital of Guizhou Medical University;Department of General Surgery, People’s Hospital of Yinjiang Autonomous County

关键词: Sleep duration;    sleep apnea;    shift work;    colorectal neoplasms;    meta-analysis;   

DOI  :  10.21037/jgo-22-682

学科分类：肿瘤学

来源: Pioneer Bioscience Publishing Company

【 摘 要 】

Background: Although studies have reported that certain sleep characteristics, such as sleep duration and sleep apnea, are linked to the risk of colorectal cancer (CRC), this link remains contentious because of the limited evidence from individual studies. Furthermore, evidence indicated that shift work involving circadian disruption as a probable human carcinogen. This systematic review and meta-analysis aimed to examine the associations between sleep duration, sleep apnea, and shift work with the risk of colorectal neoplasms, including CRC and colorectal adenoma (CRA). Methods: We conducted a comprehensive literature search in PubMed, Embase, and Web of Science databases. The inclusion criteria were determined using PICOS principles. Observational studies reporting associations of sleep duration, sleep apnea, or shift work with risk of CRC or CRA were included. We assessed the risk of bias on the basis of the Newcastle–Ottawa Scale. Results: 0.05). The sensitivity analysis showed that no individual study substantially influenced the pooled RRs for colorectal neoplasms and CRC. Conclusions: Our findings suggest the significant positive association of long sleep duration and sleep apnea with risk of colorectal neoplasms and CRC. Given that sleep characteristics may be a potentially modifiable risk factor for colorectal neoplasms, further understanding of its role in carcinogenesis will provide valuable insight for cancer prevention.

【 授权许可】

Unknown