Etiology and Clinical Features of Bacterial Meningitis in Adults at National Hospital for Tropical Diseases during 2015–2018

Japanese journal of infectious diseases

article

Ha Thanh Bui¹  Viet Huu Hoang²  Toan Van Ngo³  Huy Vu Bui⁴ 

[1] Hanoi Medical University;Emergency Department, National Hospital for Tropical Diseases;Department of Environmental Health, Hanoi Medical University;Infectious Diseases Department, Hanoi Medical University;Pediatrics Department, National Hospital for Tropical Diseases

关键词: meningitis;    adult;    clinical;    etiology;    Streptococcus suis;   

DOI  :  10.7883/yoken.JJID.2021.789

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

To evaluate the etiology and clinical features of bacterial meningitis (BM) in adults during 2015–2018 in Vietnam, a retrospective study using 102 patients was performed at the National Hospital of Tropical Diseases. BM occurred throughout the year, peaking in July–September. A total of 80.4% BM patients were males over 40 years old. The proportion of patients with underlying diseases was 41.2% and those in contact with pigs or pork products was 30.4%. Common manifestations include stiff neck, Kernig’s sign, headache, fever/hypothermia, and altered consciousness. The cerebrospinal fluid (CSF) had high protein concentration (median: 3.2 g/L, range: 1.3–6.2) and leukocytes (median: 1,312 cell/mm3, range: 234–2,943). Moreover, 29.4% meningitis cases were associated with septicemia. Streptococcus suis was the main cause (72.5%), followed by Pneumococcus (6.8%) and a few other bacteria. Factors associated with S. suis risk were male sex (OR: 8.29, 95% CI: 2.83–24.33), over 40 years old (OR: 3.55, 95% CI: 1.28–9.87), drinking habits (OR: 3.78, 95% CI: 1.03–13.72), headache (OR: 6.19, 95% CI: 2.17–17.65), fever/hypothermia (OR: 5.17, 95% CI: 1.97–13.56) and ≥2.0 ng/mL procalcitonin (OR: 2.72, 95% CI: 1.07–6.89). Education on S. suis and nosocomial infection prevention, as well as pneumococcal vaccination use, should be continued.

【 授权许可】

Unknown