Risk Factors for Candidiasis as an Intra-Abdominal Infection after Gastrectomy in Patients with Gastric Cancer

Japanese journal of infectious diseases

article

Kazuya Higashizono¹  Erina Nagai¹  Masato Nishida¹  Shinsuke Sato¹  Ko Ohata¹  Masaya Watanabe¹  Hideyuki Kanemoto¹  Noriyuki Oba¹  Kyota Tatsuta¹  Yusuke Taki¹  Eiji Nakatani² 

[1] Department of Gastroenterological Surgery, Shizuoka General Hospital;Division of Statistical Analysis, Research Support Center, Shizuoka General Hospital

关键词: stomach neoplasms;    intra-abdominal infection;    Candida;    gastrectomy;   

DOI  :  10.7883/yoken.JJID.2021.893

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Intra-abdominal infections (IAIs) develop in 2.4%–26.6% of patients who underwent gastrectomy for gastric cancer and are occasionally serious. However, there are few reports on the causative organisms of IAI following upper gastrointestinal tract surgery and subsequent risk factors for Candida infections. This study aimed to identify the microorganisms that cause IAIs after gastrectomy and risk factors for Candida-related IAI. The records of patients who underwent gastrectomy for gastric cancer between January 2009 and December 2019 at Shizuoka General Hospital were retrospectively collected. Patients with IAIs of grade II or higher, as measured by the Clavien–Dindo classification, were included in the analysis. The selected patients were divided into the Candida and non-Candida groups according to the presence or absence of Candida as the causative organism. Of 1,379 patients, 56 (4.1%) were diagnosed with IAIs after gastrectomy. Fifty-two patients were included in the study based on culture analyses. A total of 111 strains and 28 bacterial species were isolated during the initial culture test. Candida constituted 7.2% of all identified pathogens. Regarding the risk factors for Candida-related IAI, a history of antimicrobial use and ≥ 4 postoperative days of IAI development were independent risk factors for Candida-related IAI.

【 授权许可】

Unknown