Influenza A Virus Infection in Domestic Ferrets

Japanese journal of infectious diseases

article

Yudai Kuroda¹  Ai Okada¹  Hiroshi Shimoda¹  Yasutsugu Miwa³  Akiko Watamori³  Hiroho Ishida⁴  Shin Murakami⁴  Ayato Takada⁵  Taisuke Horimoto⁴  Ken Maeda¹ 

[1] Department of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University;Department of Veterinary Science, National Institute of Infectious Diseases;Miwa Exotic Animal Hospital;Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Global Institution for Collaborative Research and Education, Global Station for Zoonosis Control, Hokkaido University

关键词: ferret;    influenza;    seroprevalence;    reverse zoonosis;   

DOI  :  10.7883/yoken.JJID.2021.745

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, a survey was performed to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. Using enzyme-linked immunosorbent assay for hemagglutinin proteins, we found a high positive rate for the H1 (24.1%) and H3 (5.2%) subtypes. The results were confirmed by a virus neutralization test for representative antibody-positive serum samples. We also detected hemagglutinin and neuraminidase genes in two ferrets showing acute respiratory disease and whose owner was diagnosed with IAV infection; a human H1N1pdm virus was isolated from one of these ferrets. Our findings suggest that attention should be paid to IAV infection from humans to ferrets and vice versa.

【 授权许可】

Unknown