Bayesian post-hoc analysis of chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus

The Journal of Thoracic and Cardiovascular Surgery

article

Nicolas Zhou¹  Kyung Hyun Lee²  Claudia Pedroza²  Wayne L. Hofstetter³ 

[1] Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center;Center for Clinical Research and Evidence-Based Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston;Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex关键词: esophageal;    squamous cell carcinoma;    trimodality;    bimodality;    Bayesian;    surgery;    chemotherapy;    radiation;    chemoradiation;   

DOI  :  10.1016/j.jtcvs.2021.11.056

学科分类：心脏病和心血管学

来源: Mosby, Inc.

【 摘 要 】

Randomized controlled trials (RCTs) are considered the greatest level of evidence in clinical research. In lower-prevalence cancers, where there is a paucity of RCTs, clinical practice may be heavily influenced by the results of a single randomized clinical trial. However, one must always carefully scrutinize the methodology of a trial before interpreting RCT results. In reality, RCTs are often more difficult to carry out and implement than studies in a controlled biological environment and might not replicate real-life decision-making strategies.

【 授权许可】

Unknown