Lung metastasectomy for colorectal cancer: The impression of benefit from uncontrolled studies was not supported in a randomized controlled trial

The Journal of Thoracic and Cardiovascular Surgery

article

Tom Treasure¹  Joel Dunning²  Norman R. Williams³  Fergus Macbeth⁴ 

[1] Clinical Operational Research Unit, University College London;James Cook University Hospital;Surgical and Interventional Trials Unit, University College London;Centre for Trials Research, Cardiff University

关键词: metastasectomy;    colorectal cancer;   

DOI  :  10.1016/j.jtcvs.2021.01.142

学科分类：心脏病和心血管学

来源: Mosby, Inc.

【 摘 要 】

The Society of Thoracic Surgeons expert consensus document on pulmonary metastasectomy states:Since 1980, greater than 1,000 publications addressed PM [pulmonary metastasectomy], without a single randomized controlled trial. Most of the studies are surgical series, usually from a single institution, and include single or multiple pathologies. The pool of patients from which metastasectomy patients derive is not reported, allowing no comparative survival analysis. Historical controls are used or metastatic disease survival is assumed to be zero, a contention not supported by the literature.

【 授权许可】

Unknown