Nanoparticle/DNAzyme Based Biosensors for Heavy-Metal Ion Detection: Effect of DNAzyme Surface Modifications on Device Sensitivity

Engineering Proceedings

article

Evangelos Aslanidis¹  Evengelos Skotadis¹  Chryssi Panagopoulou¹  Annita Rapesi¹  Georgia Tzourmana¹  George Tsekenis²  Dimitris Tsoukalas¹ 

[1] Department of Applied Physics, National Technical University of Athens;Biomedical Research Foundation of the Academy of Athens

关键词: nanoparticles;    platinum nanoparticles;    DNAzymes;    biosensor;    heavy-metal ions;    DNAzymes immobilization;    lead ions;   

DOI  :  10.3390/IECB2023-14581

来源: mdpi

【 摘 要 】

In this work, a biosensor for heavy metal-ion detection, based on platinum nanoparticles (Pt NPs) and DNAzymes, is presented. Two chemical modification groups were utilized for the DNAzymes’ immobilization on the Pt NPs film. The biosensors were characterized concerning their ability to detect Lead (Pb2+) ions in buffer solutions. Both immobilization techniques exhibit great sensitivity with a detection limit of 25 nM.

【 授权许可】

Unknown