Directional Hemispherical Reflectance as a Quick Method for Analysis of Degradation Processes in Commercial Effervescent Tablets

Engineering Proceedings

article

Beata Sarecka-Hujar¹  Michał Meisner¹  Beata Szulc-Musioł²  Piotr Duda³ 

[1] Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice;Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice;Institute of Biomedical Engineering, Faculty of Science and Technology, University of Silesia

关键词: effervescent tablets;    solid dosage forms;    directional hemispherical reflectance;    reflectometer;   

DOI  :  10.3390/ASEC2022-13768

来源: mdpi

【 摘 要 】

In the present study, we aimed to evaluate the total directional hemispherical reflectance (THR) in expired and unexpired effervescent tablets. Expired tablets were stored in ambient conditions. The THR was measured using a SOC-410 Directional Hemispherical Reflectometer (Surface Optics Corporation, San Diego, CA, USA) in seven wavelength bands from ultraviolet, through visible, to near-infrared light. Significantly higher values of THR for the ranges of 700–1100 nm and 1700–2500 nm were observed for expired tablets than for unexpired tablets (p < 0.001). The measurement of THR may be a rapid method to detect adverse physicochemical changes in effervescent tablets and can be used for a further detailed evaluation of active pharmaceutical ingredients (APIs) and related degradation products.

【 授权许可】

Unknown