The Crosslinker Matters: Vinylimidazole-Based Anion Exchange Polymer for Dispersive Solid-Phase Extraction of Phenolic Acids

Separations

article

Matthias Harder¹  Rania Bakry¹  Felix Lackner¹  Paul Mayer¹  Christoph Kappacher¹  Christoph Grießer²  Sandro Neuner³  Christian W. Huck¹  Günther K. Bonn¹  Matthias Rainer¹ 

[1] Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University of Innsbruck;Institute of Physical Chemistry, Leopold-Franzens University of Innsbruck;Department of General, Inorganic and Theoretical Chemistry, Leopold-Franzens University of Innsbruck;ADSI-Austrian Drug Screening Institute

关键词: crosslinker;    phenolic acids;    vinylimidazole;    anion exchanger;    co-polymer;    solid-phase extraction;    sustainable analytical sample preparation;   

DOI  :  10.3390/separations9030072

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Crosslinkers are indispensable constituents for the preparation of SPE materials with ethylene glycol dimethacrylate (EGDMA) and divinylbenzene (DVB) among the most prominent representatives. A crosslinker that has not yet been used for the preparation of SPE sorbents is 3,3’-(hexane-1,6-diyl)bis(1-vinylimidazolium) bromide [C6-bis-VIM] [Br]. In this study, we synthesized differently crosslinked vinylimidazole polymers with EGDMA, DVB and [C6-bis-VIM] [Br] and evaluated their extraction efficiencies towards phenolic acids. Dispersive SPE experiments performed with the [C6-bis-VIM] [Br] crosslinked polymers exhibited significantly higher extraction recoveries for the majority of analytes. Due to these promising results, the [C6-bis-VIM] [Br] crosslinked polymer was optimized in terms of the monomer to crosslinker ratio and an efficient dispersive SPE protocol was developed, with maximum recoveries ranging from 84.1–92.5% and RSD values ˂ 1%. The developed extraction procedure was also applied to cartridges resulting in recoveries between 97.2 and 98.5%, which were on average 5% higher than with the commercial anion exchange sorbent Oasis® MAX. Furthermore, the sorbent was regenerated showing a good reusability for the majority of analytes. In conclusion, this study clearly highlights the yet untapped potential of the crosslinker, [C6-bis-VIM] [Br], with respect to the synthesis of efficient anion exchange polymers for SPE.

【 授权许可】

CC BY