Biomarkers in Patients with Hand-Arm Vibration Injury Entailing Raynaud’s Phenomenon and Cold Sensitivity, Compared to Referents

Proceedings

article

Eva Tekavec¹  Tohr Nilsson²  Lars B. Dahlin³  Anna Axmon¹  Catarina Nordander¹  Jakob Riddar¹  Monica Kåredal¹ 

[1]Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University

[2]Division of Sustainable Health and Medicine, Department of Public Health and Clinical Medicine, Umeå University

[3]Department of Translational Medicine—Hand Surgery, Lund University

关键词: hand-arm vibration syndrome;    hand arm vibration injury;    Raynaud’s phenomenon;    cold sensitivity;    biomarkers;    thrombomodulin;    glial fibrillary acidic protein;    endothelial dysfunction;   

DOI  :  10.3390/proceedings2023086027

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

The clinical evaluation of patients with neurosensory injury is based on quantitative sensory testing. Such tests require the patient’s cooperation, which may sometimes hinder a correct diagnosis. Objective findings, e.g., with biomarkers, would therefore be valuable. We evaluated serum biomarkers of vascular and neural injury in 92 patients with vibration injuries and in 64 referents. Thrombomodulin (TM), a biomarker for endothelial damage, was elevated in HAVS patients with Raynaud’s phenomenon (RP) compared to those without, as it also was in comparison to the referents. In the patients without RP, those with increased cold sensitivity showed somewhat higher—but not significantly different—values of TM (p = 0.4) than those without increased cold sensitivity, indicating an endothelial dysfunction or injury.

【 授权许可】

CC BY