Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria

Tropical Medicine and Infectious Disease

article

Miles B. Markus¹ 

[1] Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of Witwatersrand;School of Animal, Plant and Environmental Sciences, Faculty of Science, University of Witwatersrand

关键词: bone marrow;    hydrogen peroxide;    hypnozoite;    malaria;    Plasmodium vivax;    primaquine;    recrudescence;    relapse;    spleen;    tafenoquine;   

DOI  :  10.3390/tropicalmed8050278

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Enhanced therapeutic efficacy achieved in treating Plasmodium vivax malaria with an 8-aminoquinoline (8-AQ) drug such as primaquine (PQ) together with a partner drug such as chloroquine (CQ) is usually explained as CQ inhibiting asexual parasites in the bloodstream and PQ acting against liver stages. However, PQ’s contribution, if any, to inactivating non-circulating, extra-hepatic asexual forms, which make up the bulk of the parasite biomass in chronic P. vivax infections, remains unclear. In this opinion article, I suggest that, considering its newly described mode of action, PQ might be doing something of which we are currently unaware.

【 授权许可】

CC BY