Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador

Tropical Medicine and Infectious Disease

article

Mary K. Lynn¹  Marvin Stanley Rodriguez Aquino²  Pamela Michelle Cornejo Rivas²  Mufaro Kanyangarara¹  Stella C. W. Self¹  Berry A. Campbell³  Melissa S. Nolan¹ 

[1] Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina;Health Research and Development Center ,(CENSALUD), University of El Salvador;Department of Obstetrics and Gynecology, Prisma Health

关键词: Chagas disease;    Trypanosoma cruzi;    vertical transmission;    congenital;    El Salvador;    neglected tropical disease;    perinatal;    maternal–child health;   

DOI  :  10.3390/tropicalmed8040233

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Congenital Chagas disease is a growing concern, prioritized by the World Health Organization for public health action. El Salvador is home to some of the highest Chagas disease (Trypanosoma cruzi infection) burdens in the Americas, yet pregnancy screening remains neglected. This pilot investigation performed a maternal T. cruzi surveillance study in Western El Salvador among women presenting for labor and delivery. From 198 consented and enrolled pregnant women, 6% were T. cruzi positive by serology or molecular diagnosis. Half of the infants born to T. cruzi-positive women were admitted to the NICU for neonatal complications. Geospatial statistical clustering of cases was noted in the municipality of Jujutla. Older women and those knowing an infected relative or close friend were significantly more likely to test positive for T. cruzi infection at the time of parturition. In closing, maternal T. cruzi infections were significantly higher than national HIV or syphilis maternal rates, creating an urgent need to add T. cruzi to mandatory pregnancy screening programs.

【 授权许可】

CC BY