Tropical Medicine and Infectious Disease | |
Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador | |
article | |
Mary K. Lynn1  Marvin Stanley Rodriguez Aquino2  Pamela Michelle Cornejo Rivas2  Mufaro Kanyangarara1  Stella C. W. Self1  Berry A. Campbell3  Melissa S. Nolan1  | |
[1] Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina;Health Research and Development Center ,(CENSALUD), University of El Salvador;Department of Obstetrics and Gynecology, Prisma Health | |
关键词: Chagas disease; Trypanosoma cruzi; vertical transmission; congenital; El Salvador; neglected tropical disease; perinatal; maternal–child health; | |
DOI : 10.3390/tropicalmed8040233 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: mdpi | |
【 摘 要 】
Congenital Chagas disease is a growing concern, prioritized by the World Health Organization for public health action. El Salvador is home to some of the highest Chagas disease (Trypanosoma cruzi infection) burdens in the Americas, yet pregnancy screening remains neglected. This pilot investigation performed a maternal T. cruzi surveillance study in Western El Salvador among women presenting for labor and delivery. From 198 consented and enrolled pregnant women, 6% were T. cruzi positive by serology or molecular diagnosis. Half of the infants born to T. cruzi-positive women were admitted to the NICU for neonatal complications. Geospatial statistical clustering of cases was noted in the municipality of Jujutla. Older women and those knowing an infected relative or close friend were significantly more likely to test positive for T. cruzi infection at the time of parturition. In closing, maternal T. cruzi infections were significantly higher than national HIV or syphilis maternal rates, creating an urgent need to add T. cruzi to mandatory pregnancy screening programs.
【 授权许可】
CC BY
【 预 览 】
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RO202307010002389ZK.pdf | 3124KB | download |