Occurrence of Multidrug-Resistant Strains of Acinetobacter spp.: An Emerging Threat for Nosocomial-Borne Infection in Najran Region, KSA

Tropical Medicine and Infectious Disease

article

Abdullah I. Aedh¹  Ali Dhafer Al-Swedan²  Asiri Ahmed Mohammed³  Batool Mubarak Alwadai³  Ahlam Yahya Alyami³  Esraa Amer Alsaaed³  Nouf Mubarak Almurdhimah³  Mohamed Soliman Zaki⁴  Alyaa E. Othman⁵  Abdulkarim Hasan⁶ 

[1] Consultant of Internal Medicine and Critical Care, Department of Internal Medicine, Najran University Hospital, Najran University;Infectious Diseases and Internal Medicine, King Khalid Hospital, Najran University;Senior Medical Residents, King Khalid Hospital, Najran University;Department of Chest Diseases, Faculty of Medicine, Al-Azhar University;Department of Infectious Diseases, Faculty of Medicine, Suez Canal University;Department of Pathology, Faculty of Medicine, Al-Azhar University;Department of Laboratory Medicine, Prince Mishari bin Saud Hospital, Saudi Ministry of Health

关键词: Acinetobacter;    antimicrobial-resistant;    epidemic infection outbreaks;    nosocomial-borne infection;   

DOI  :  10.3390/tropicalmed8020108

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Multidrug-resistant strains are frequent causes of nosocomial infections. The majority of nosocomial infections, particularly in critical care units (ICU), have been linked to A. baumannii, which has major clinical significance. The current paper attempts to identify the potential risk and prognosis factors for acquiring an infection due to A. baumannii compared to that of other nosocomial bacteria. In our study, we employed antibiotics generally prescribed for the initial course of treatment such as colistin, meropenem, amikacin, trimethoprime-sulfamethoxazole, levofloxacin, gentamicin, ciprofloxacin, and piperacillin-tazobactam. We found that the isolated A. baumannii were resistant at a high rate to meropenem, piperacillin–tazobactam, amikacin, levofloxacin, and ciprofloxacin, while they were partially susceptible to trimethoprim-sulfamethoxazole. Our study revealed that A. baumannii was most susceptible to gentamicin and colistin at 85.8% and 92.9%, respectively, whereas the combination of colistin and trimethoprim/sulfamethoxazole was 100% active. The patients were the primary source of infection with A. baumannii, followed by inanimate objects present in the ICU and hospital premises, and then the hospital staff who were taking care of the ICU patients. Gentamicin and colistin were the most sensitive antibiotics; of the 13 tested in total, the rate of drug resistance was above 50%. The very high rate of antibiotic resistance is alarming.

【 授权许可】

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