The Role of Chloroviruses as Possible Infectious Agents for Human Health: Putative Mechanisms of ATCV-1 Infection and Potential Routes of Transmission

Tropical Medicine and Infectious Disease

article

Yury V. Zhernov¹  Sonya O. Vysochanskaya¹  Artem A. Basov¹  Vitaly A. Sukhov¹  Anton A. Simanovsky¹  Inna A. Fadeeva⁷  Roman V. Polibin⁹  Ekaterina A. Sidorova¹  Denis V. Shcherbakov¹  Oleg V. Mitrokhin¹ 

[1] Department of General Hygiene, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow StateMedical University ,(Sechenov University);Center of Life Sciences, Skolkovo Institute of Science and Technology;Department of Chemistry, Lomonosov Moscow State University;Center for Medical Anthropology, N.N. Miklukho-Maclay Institute of Ethnology and Anthropology of the Russian Academy of Sciences;Department of Medical and Biological Disciplines, Reaviz Medical University;Diphtheria and Pertussis Surveillance Laboratory, G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology;Department of English Language, Institute of World Economy, Diplomatic Academy of the Russian Foreign Ministry;Department of Public Administration in Foreign Policy, Diplomatic Academy of the Russian Foreign Ministry;Department of Epidemiology and Evidence-Based Medicine, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow State Medical University ,(Sechenov University)

关键词: Chlorovirus;    ATCV-1;    Chlorella;    neuroinflammation;    cognitive function;    nervous system infections;    freshwater sources;   

DOI  :  10.3390/tropicalmed8010040

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

The Chlorovirus genus of the Phycodnaviridae family includes large viruses with a double-stranded DNA genome. Chloroviruses are widely distributed in freshwater bodies around the world and have been isolated from freshwater sources in Europe, Asia, Australia, and North and South America. One representative of chloroviruses is Acanthocystis turfacea chlorella virus 1 (ATCV-1), which is hosted by Chlorella heliozoae. A few publications in the last ten years about the potential effects of ATCV-1 on the human brain sparked interest among specialists in the field of human infectious pathology. The goal of our viewpoint was to compile the scant research on the effects of ATCV-1 on the human body, to demonstrate the role of chloroviruses as new possible infectious agents for human health, and to indicate potential routes of virus transmission. We believe that ATCV-1 transmission routes remain unexplored. We also question whether chlorella-based nutritional supplements are dangerous for ATCV-1 infections. Further research will help to identify the routes of infection, the cell types in which ATCV-1 can persist, and the pathological mechanisms of the virus’s effect on the human body.

【 授权许可】

CC BY