Efficacy Assessment of Autodissemination Using Pyriproxyfen-Treated Ovitraps in the Reduction of Dengue Incidence in Parañaque City, Philippines: A Spatial Analysis

Tropical Medicine and Infectious Disease

article

Antonio D. Ligsay¹  Zypher Jude G. Regencia⁴  Kristan Jela M. Tambio²  Michelle Joyce M. Aytona²  Alain Jason A. Generale²  Grecebio Jonathan D. Alejandro¹  Jacquiline S. Tychuaco¹  Lilian A. De las Llagas⁷  Emmanuel S. Baja⁴  Richard Edward L. Paul⁸ 

[1] The Graduate School, University of Santo Tomas España Blvd.;Clinical Research Section, St. Luke’s College of Medicine—William H. Quasha Memorial;Department of Biological Sciences, College of Science, University of Santo Tomas España Blvd.;Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila;Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila;Department of Biology, College of Science, Polytechnic University of the Philippines;Department of Parasitology, College of Public Health, University of the Philippines Manila 625 Pedro Gil St.;Institut Pasteur, Université de Paris, Centre National de la Recherche Scientifique

关键词: autodissemination;    dengue;    ovitraps;    Philippines;    pyriproxyfen;    spatial analysis;   

DOI  :  10.3390/tropicalmed8010066

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Dengue is one of the most important vector-borne diseases worldwide and is a significant public health problem in the tropics. Mosquito control continues to be the primary approach to reducing the disease burden and spread of dengue virus (DENV). Aside from the traditional larviciding and adulticiding interventions, autodissemination using pyriproxyfen-treated (AD-PPF) ovitraps is one of the promising methods to complement existing vector control strategies. Our paper assessed the efficacy of AD-PPF in reducing DENV infections in two barangays in Parañaque City. Using saliva samples from the participants from both the control and intervention sites, we collected the seroprevalence data for three months in each of the two years. Spatial analysis was conducted to determine hotspot areas and identify DENV infection distributions across the trial periods. The results showed that the intervention site was identified as having a clustering of DENV infections in Month 0 of Year 1 and shifted to a random dispersion of dengue cases at the end of Month 3 in Year 2. The disappearance of the clustering of the intervention site translates to a decrease in the cases of DENV infection relative to the control site. Furthermore, we also identified that DENV transmission occurred at a small-scale level that did not go beyond 86 m. In conclusion, AD-PPF is suggested to be an effective strategy and may be used as an additional vector control approach, albeit based on this short-term implementation.

【 授权许可】

CC BY