Simultaneous Quantification of Some Fluoroquinolone Residues in Real Wastewater Effluents Using CZE

Separations

article

Sherif A. Abdel-Gawad¹  Ali Altharawi¹ 

[1] Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University;Analytical Chemistry Department, Faculty of Pharmacy, Cairo University

关键词: electro-osmotic flow;    wastewater effluents;    fluoroquinolones;    CZE;    solid-phase extraction;   

DOI  :  10.3390/separations10050292

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Since active pharmaceutical ingredients (APIs) are directly related to human health, monitoring and quantifying them in the environment is a crucial and challenging issue. Using capillary-zone electrophoresis (CZE), four frequently used fluoroquinolones (FQs), ciprofloxacin, sparfloxacin, moxifloxacin, and gatifloxacin, were efficiently isolated and measured in pharmaceutical industrial wastewater. Solid-phase extraction (SPE) was developed and used as an efficient sample pretreatment procedure. The capillary electrophoretic procedure’s various parameters were tuned to produce the optimal separation pattern for the drugs under consideration. All of the drugs under study were quantified in a concentration range of 0.5 to 50 µg/mL. After full assay validation in compliance with ICH-Q2B criteria, real wastewater samples were subjected to effective SPE, and the proposed assay was successfully used to determine the examined FQs in real wastewater samples.

【 授权许可】

CC BY