Delayed Graft Function and Acute Rejection in Kidney Transplant Patients with Positive Panel-Reactive Antibody and Negative Donor-Specific Antibodies

Nephro-Urology Monthly

article

Ha Nguyen Thi Thu¹  Manh Bui Van¹  Dung Nguyen Thi Thuy¹  Kien Truong Quy¹  Duc Nguyen Van¹  Van Diem Thi¹  Ha Do Manh¹  Dai Do Khac²  Dung Nguyen Dang²  Quyet Do²  Toan Pham Quoc¹  Thang Le Viet¹ 

[1] Military Hospital 103;Vietnam Military Medical University

关键词: Delayed Graft Function;    Graft Rejection;    HLA Antigens;   

DOI  :  10.5812/numonthly.107969

学科分类：基础医学

来源: Kowsar Corporation

【 摘 要 】

Background: Delayed graft function (DGF) and acute rejection (AR) are common complications in kidney transplant patients. Objectives: The study evaluated DGF and AR in highly sensitized patients and their effects on kidney function for six months post-transplantation. Methods: We enrolled 95 patients with kidney transplants from living donors who were divided into two groups. Group 1 included 47 highly sensitized patients with panel reactive antibody (PRA) < 20.0% and negative donor-specific antigen, and group 2 included 48 patients with negative PRA. All patients were followed for the state of DGF, AR, and kidney function for six months. Results: Group 1 showed a significantly higher proportion of DGF and AR than group 2 (27.7% versus 2.1%, P < 0.001 and 14.9% versus 2.1%, P = 0.031, respectively). The rates of positive PRA in DGF and AR patients were significantly higher than those in non-DGF and non-AR patients (92.9% versus 42.0%, P < 0.001 and 87.5% versus 46.0%, P = 0.031, respectively). Transplanted kidney function was significantly worse in patients with PRA and DGF and/or AR than in patients with negative PRA and non-DGF and non-AR only in the seventh-day post-transplantation. Conclusions: Kidney transplant in highly sensitized patients with positive PRA was related to the increased ratio of DGF and AR.

【 授权许可】

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