Effect of Stewartia koreana Boiling Extract (SKBE) on Osteoarthritis and Purification of Spinasterol From SKBE

Journal of the Korean Chemical Society

article

Sang Min Lee¹  Hye Jin Moon¹  Hong Joon Yoon¹  Chun soo Na²  Jin beom Kim²  Dae Seung Na²  Tae Hoon Lee¹  Hakwon Kim¹ 

[1]Department of Applied Chemistry and Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University

[2]Lifetree Co.Ltd.

关键词: Stewartia koreana boiling extract;    Osteoarthritis;    Active ingredient;    Inflammatory;    α-Spinasterol;   

DOI  :  10.5012/jkcs.2023.67.2.129

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Osteoarthritis is to the abnormality of the inflammatory response of joint tissue caused by various causes suchas aging, and muscle loss. In this study, the activity in joint inflammation was verified using SKBE, a plant extract, and theexpression levels of arthritis-inducing proteins including MMP-1, MMP-3, MMP-13, and collagen type II in vitro were compared and analyzed. Furthermore, we synthesized α-spinasterol, an active ingredient of SKBE, by the previously reported synthesis method and these findings could provide a new starting point for the development of treatments for osteoarthritis.

【 授权许可】

Unknown