Study of Glycyrrhizic Acid:menthol Supramolecular Complexes on Mitochondrial Functional Activity in in-vitro Experiments

Journal of the Korean Chemical Society

article

L. A. Еttibaeva¹  U. K. Abdurakhmanova¹  A. D. Matchanov² 

[1] Department of Chemistry, Gulistan State University;Head of the Experimental Technology Laboratory, Institute of Bioorganic Chemistry

关键词: Menthol;    Glycyrrhizic acid;    Homeostasis;    Aloxan diabetes;    Glycogen;    Lipid peroxidation;    Supramolecular complex;   

DOI  :  10.5012/jkcs.2023.67.2.99

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Here we present how a supramolecular complex of Glycyrrhizic acid (GA) with Menthol (Mt) affects the bloodglucose levels and glycogen synthesis in the liver of rats in in-vivo experiments with diabetes caused by alloxan. We haveshown that Menthol, Glycyrrhizic acid and GA:Mt supramolecular complexes can restore functional dysfunction of the livermitochondria in alloxan diabetes, i.e., inhibit lipid peroxidation. The hypoglycemic activity and mitochondrial membrane stabilizing properties of the supramolecular complex GA:Mt (4:1) in alloxan diabetes were more pronounced than those of menthol, GA and its GA:Mt (2:1) and GA: Mt (9:1) supramolecular complexes.

【 授权许可】

Unknown