期刊论文详细信息
The Journal of Veterinary Medical Science | |
Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction | |
article | |
Nobue KUNIYOSHI1  Saki HANADA2  Reina ANDO2  Lita Rakhma YUSTINASARI3  Maria KURATOMI2  Seizaburo KAGAWA2  Hiroyuki IMAI2  Ken Takeshi KUSAKABE1  | |
[1]Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University | |
[2]Laboratory of Veterinary Anatomy, Joint Faculty of Veterinary Medicine, Yamaguchi University | |
[3]Laboratory of Basic Veterinary Science, Joint Graduate School of Veterinary Medicine, Yamaguchi University | |
[4]Division of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga | |
关键词: complement; Crry; decidual cell; trophoblast giant cell; | |
DOI : 10.1292/jvms.22-0286 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
In mammals, immune tolerance against fetal tissue has been established for normal pregnancy progression. It is known that Crry regulates complemental activity to prevent injury of the mouse embryo and extra-embryonic tissue. This study aimed to examine the expression appearance and normal localization sites of Crry in the mouse placenta. Also, the emergency responses of Crry were verified at the time of experimental miscarriage induction. Moreover, we investigated an existing similar protein of Crry in animal placentas other than mice. Crry expression level showed a peak at day 8.5 of pregnancy. Trophoblast giant cells and decidual cells indicated a positive reaction to anti-Crry antibody. After treatments of interferon-γ, Crry expression was increased significantly in the survived implantation sites as compared with the controls. However, there was no significant difference in the miscarriage-initiated sites. It disclosed that Crry distributes from the early to middle periods of the placentas and involves complement regulation at the extraembryonic tissue and decidua basalis. Crry also showed an ability to respond to risk against external initiation for urgent miscarriage. Finally, we found anti-mouse Crry antibody-bound proteins in the placenta of many animals. It suggests a potency of Crry to make an environment of immune tolerance in many types of mammal placentas.【 授权许可】
Unknown
【 预 览 】
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RO202306300003939ZK.pdf | 1840KB | download |