Temporal patterns of increased growth hormone secretion in mice after oral administration of L-ornithine: possible involvement of ghrelin receptors

The Journal of Veterinary Medical Science

article

Emi TANIGUCHI¹  Ayumi HATTORI¹  Kaito KUROGI¹  Yukihiro HISHIDA²  Fumiko WATANABE²  Mitsuhiro FURUSE¹  Shinobu YASUO¹ 

[1] Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University;R&I Center, Kyowa Hakko Bio Co., Ltd.

关键词: ghrelin;    growth hormone;    growth hormone-releasing hormone;    ornithine;    somatostatin;   

DOI  :  10.1292/jvms.22-0125

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

l-Ornithine is known to stimulate growth hormone (GH) release in mammals. Here, we demonstrated that increases in plasma GH levels after oral administration of l-ornithine were first observed 150 min after administration, and the elevated levels were sustained for more than 90 min in mice. The increase was significantly delayed compared with the reported timing of plasma and tissue levels of l-ornithine after administration. The l-ornithine-induced increase in GH release was completely blocked by [D-Lys3]-GHRP-6, a ghrelin receptor antagonist, but not by cyclosomatostatin or JV-1-38, antagonists of somatostatin and GH-releasing hormone, respectively. These results suggest the involvement of ghrelin receptor-mediated pathways in l-ornithine-induced increases in GH release.

【 授权许可】

Unknown