Whole-genome sequencing of live attenuated bovine adenovirus type 7 vaccine strain TS-GT suggests biomarkers for virulence attenuation

The Journal of Veterinary Medical Science

article

Asuka KUMAGAI¹  Sayo KAJIKAWA²  Ayako MIYAZAKI¹  Shinichi HATAMA¹ 

[1] National Institute of Animal Health, National Agriculture and Food Research Organization;Himeji Livestock Hygiene Service Center;Strategic Planning Headquarters, National Agriculture and Food Research Organization

关键词: attenuation;    bovine adenovirus;    inverted terminal repeat;    pVI;   

DOI  :  10.1292/jvms.22-0198

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Bovine adenovirus type 7 (BAdV-7) is one of the most important respiratory and enteric pathogens in the cattle industry. Although live attenuated vaccines are used to control the virus in Japan, limited information is available on the genomic regions that determine viral pathogenicity. We determined the complete genome sequence of the attenuated BAdV-7 strain TS-GT. The genome is 30,052 bp long and contains 45-bp inverted terminal repeats and 30 predicted genes. A genome sequence comparison showed that 99.9% of the TS-GT genome is identical to the prototypic and pathogenic BAdV-7 strain Fukuroi; however, the TS-GT genome contains a novel mutation and four indels. We describe here potential relationships between these genomic changes and the biological characteristics of BAdV-7.

【 授权许可】

Unknown