Canine intracranial meningioma with rosette-like collagen deposits

The Journal of Veterinary Medical Science

article

Ryo SAITO¹  James K. CHAMBERS¹  Yoshiki SUGIYAMA²  Kazuyuki UCHIDA¹ 

[1] Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Uminonakamichi Animal Clinic

关键词: brain;    collagen;    dog;    meningioma;    rosette;   

DOI  :  10.1292/jvms.22-0074

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

A 13-year-old female Miniature Dachshund showed seizures and an intracranial mass was seen in the left temporal lobe. Three months after first surgical resection, a recurrence lesion was recognized. Histopathologically, proliferation of spindle cells with diffuse rosette-like eosinophilic deposits, which stained blue with Masson’s trichrome stain, was observed. In electron microscopy, the rosette-like deposits were consisted of bundles of minute filaments which were assumed to be collagenous fibrils. Immunohistochemically, the neoplastic cells were positive for vimentin and cytokeratin, and negative for E-cadherin, S100, glial fibrillary acidic protein (GFAP), oligodendrocyte transcription factor (Olig2), and CD204. The rosette-like collagen deposits were positive for type 4 collagen and negative for type 1 collagen. In this report, we describe histopathological features of a canine meningioma with the rosette-like collagen deposits.

【 授权许可】

Unknown