Characterization of mucin gene expression and goblet cell proportion in inflammatory colorectal polyps in miniature dachshunds

The Journal of Veterinary Medical Science

article

Noriyuki NAGATA¹  Hiroshi OHTA²  Nozomu YOKOYAMA¹  Yong Bin TEOH³  Noboru SASAKI³  Kensuke NAKAMURA³  Mitsuyoshi TAKIGUCHI³ 

[1] Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University;Companion Animal Internal Medicine, Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University;Laboratory of Veterinary Internal Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University

关键词: canine;    goblet cell;    inflammatory colorectal polyp;    mucin;   

DOI  :  10.1292/jvms.22-0076

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Hyperplastic goblet cells and abundant mucus are significant characteristics of inflammatory colorectal polyps (ICRPs) in miniature dachshunds. In this study, selected mucin gene expressions and goblet cell proportions were evaluated in miniature dachshunds with ICRPs and in healthy dogs. Mucin 2 (MUC2) gene expression was not significantly different among the groups, whereas mucin 5AC (MUC5AC) gene expression was significantly higher in the polypoid lesions than in healthy colonic mucosa. Although the percentage of goblet cells in the upper crypt regions did not significantly differ between the groups, that in the lower crypt regions was significantly decreased in polypoid lesions. In conclusion, increased MUC5AC gene expression and goblet cell proportion changes may be associated with the pathogenesis of ICRPs.

【 授权许可】

Unknown