Histological and immunohistochemical features of cutaneous mast cell tumor in six captive four-toed hedgehogs ( Atelerix albiventris )

The Journal of Veterinary Medical Science

article

Nguyen Vu SON¹  James Kenn CHAMBERS¹  Makoto NAKATA³  Yasutsugu MIWA³  Hiroyuki NAKAYAMA¹  Kazuyuki UCHIDA¹ 

[1] Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Veterinary Pathology, Faculty of Veterinary Medicine, Vietnam National University of Agriculture;Miwa Exotic Animal Hospital;Vision Vets Group Lab

关键词: cutaneous mast cell tumor;    four-toed hedgehog (Atelerix albiventris);    histopathology;    immunohistochemistry;   

DOI  :  10.1292/jvms.21-0560

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

This report described the histopathological and immunohistochemical features of cutaneous mast cell tumor (MCT) in six hedgehogs. The hedgehogs presented single cutaneous mass with ulcer and crusting. Histologically, the neoplastic lesions were characterized by the proliferation of well-differentiated mast cells (3 cases), and atypical mast cells (3 cases) with one atypical histiocytic morphology. Immunohistochemically, tumor cells were positive for KIT and mast cell tryptase, and were negative for Iba-1. In well-differentiated MCT, all patients were clinically improved and survived more than 365 days after surgical excision, whereas an atypical histiocytic MCT showed aggressive behavior with re-recurrence, and the animal died 115 days after surgery. These findings suggest that, compatible with other animals, well-differentiated MCT has a better prognosis in hedgehogs.

【 授权许可】

Unknown