Association between the intake of plant and animal proteins and the serum fibroblast growth factor-23 level in patients with chronic kidney disease analyzed by the isocaloric substitution model

Endocrine journal

article

Masaki Yoshioka¹  Keisei Kosaki³  Masahiro Matsui²  Shoya Mori¹  Natsumi Nishitani¹  Chie Saito⁴  Kunihiro Yamagata⁴  Makoto Kuro-o⁶  Seiji Maeda² 

[1] Graduate School of Comprehensive Human Sciences, University of Tsukuba;Japan Society for the Promotion of Science;Faculty of Health and Sport Sciences, University of Tsukuba;Faculty of Medicine, University of Tsukuba;R&D Center for Smart Wellness City Policies, University of Tsukuba;Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University;Faculty of Sport Sciences, Waseda University

关键词: Dietary protein;    Asian diets;    Phosphate metabolism;    Isocaloric substitution modeling;   

DOI  :  10.1507/endocrj.EJ22-0063

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Fibroblast growth factor-23 (FGF23) is a phosphaturic hormone secreted by the bone in response to dietary phosphate intake. Since the phosphate content in the diet correlates with the protein content, both plant- and animal-based protein intake can increase the serum FGF23 level. However, a higher percentage of energy from plant protein than from animal protein is associated with a lower serum FGF23 level in patients with chronic kidney disease (CKD) in the United States. Since dietary habits differ between Asian and Western populations, we performed a cross-sectional study to determine the association between the percentages of energy from plant and animal proteins and the serum FGF23 level in Japanese CKD patients. In 107 non-dialysis CKD patients (age: 66 ± 9 years; estimated glomerular filtration rate: 56 ± 21 mL/min/1.73 m2), the percentages of energy from plant and animal proteins were assessed using a food frequency questionnaire based on food groups. Venous blood samples were used to measure the serum FGF23, phosphate, 1,25-dihydroxyvitamin D, and intact parathyroid hormone levels. The percentages of energy from plant and animal proteins showed a negative and positive association, respectively, with the serum FGF23 level. Furthermore, isocaloric substitution modeling showed that replacing animal protein with plant protein was associated with a low serum FGF23 level. Our findings suggest that encouraging diets with high plant protein level may prevent an increase in the serum FGF23 level in Japanese CKD patients.

【 授权许可】

Unknown