Aortic balloon valvuloplasty as a bridge to liver transplantation in a patient with severe aortic stenosis and end-stage liver disease.

Cardiologia Croatica

article

Vlado-Vlaho Ćubela¹  Maro Dragičević¹  Joško Bulum²  Tajana Filipec Kanižaj¹  Helena Jerkić.¹ 

[1] University Hospital “Merkur”;University Hospital Centre Zagreb;University of Zagreb, School of Medicine

关键词: balloon aortic valvuloplasty;    aortic stenosis;    end-stage liver disease;    orthotopic liver transplantation;   

DOI  :  10.15836/ccar2021.289

学科分类：心脏病和心血管学

来源: Hrvatsko Kardiolosko Drustvo / Croatian Cardiac Society

【 摘 要 】

Introduction: Severe aortic stenosis (AS) in patients with end-stage liver disease (ESLD) increases the morbidity and mortality of orthotopic liver transplantation (OLT). OLT is a surgical intervention with serious hemodynamic changes which can contribute to heart failure and cardiac death. Due to increased perioperative mortality, severe AS and ESLD are considered contraindications for OLT or aortic valve replacement (AVR)1 . Aortic balloon valvuloplasty (BAV) may be a reasonable therapeutic option to improve the hemodynamic status and enable OLT2. Case report: The patient was a 43-year-old female who had an OLT in 2019 due to fulminant hepatitis B. AS was detected in 2018 and it progressed to severe in 2021. In 2021, another decompensation of cirrhosis of the liver graft occurred. The patient had Child-Pugh B graft cirrhosis which is according to the available data, contraindication for cardiac surgery3. A multidisciplinary meeting was held and it was decided to do a BAV as a less invasive procedure before OLT. BAV was made with a satisfactory reduction of the transvalvular pressure gradient by 30% and with this procedure, the patient is hemodynamically in a more favorable position for OLT. Discussion: BAV was presented as a minimally invasive procedure with fewer complications to surgical replacement for AS in patient with ESLD. In practice, the procedure was proved to have a high percentage of complications and only a modest hemodynamic upgrade compared with AVR. Therefore, valvuloplasty should not be the first choice for AS. However, there are some indications for BAV such as a palliative treatment and in patients with AS and ESLD as a bridging procedure to OLT1 . This procedure enabled our patient to undergo surgery in a hemodynamically more favorable situation. It is also necessary to say that a multidisciplinary approach involving gastroenterologists, cardiologists, cardiac and abdominal surgeons, and anesthesiologists is the key in the treatment of such patients. In conclusion, in patients who are unsuitable for OLT because of AS, BAV, and then OLT may be a good approach that permits AVR posttransplantation. However further research is needed to demonstrate the advantages and disadvantages of this approach.

【 授权许可】

Unknown