The Moderating Effect of Hypericum thymbrifolium against Memory Loss and Alzheimer's Disease (Experimental Study in Mice)

Jordan Journal of Biological Sciences

article

Khayra Zerrouki¹  Leila Gadouche¹  Esra Eroglu Ozkan⁴  Afife Mat⁴ 

[1] Laboratory of Pharmacognosy and Api-Phytotherapy, Department of Biology FSNV- Mostaganem University;Department of Nutrition and Food Sciences;Nature and Life Sciences faculty -Chlef University;Department of Pharmacognosy, Faculty of Pharmacy- Istanbul University

关键词: Alzheimer’s disease (AD);    antioxidant;    Hypericum thymbrifolium;    mice;    phytotherapy;   

DOI  :  10.54319/jjbs/140216

学科分类：生物科学（综合）

来源: Hashemite University, Deanship of Research and Higher Studies

【 摘 要 】

Symptoms of neurodegenerative diseases acquired through neurologic disorder in behavior and memory are sometimes associated with severe aggression. Differences in terminology have resulted in varying estimates, but behavior disorders and memory loss appear to be characteristic of Alzheimer’s disease. This work provides a brief neurologic comparison between Alzheimer’s model and treated Alzheimer’s with Hypericum thymbrifolium known as a kind of Turkish tea. The advantages of using phytotherapy against neurodegenerative diseases, including Alzheimer’s, reduce the rate of cascade reactions of neurodegeneration and amyloid-beta synthetizes. Hypericum thymbrifolium is a species of Turkish antioxidant plant extracted and studied in Istanbul University Faculty of Pharmacy Department of Pharmacognosy. Mice were randomized into 3 groups, 6 mice each. Group 1: control; 2: Alzheimer’s model (AlCl orally+ IP D-Gal); 3: treated Alzheimer’s with 3 the ethanol extract of H. thymbrifolium. After 90 days of experimentation, neurologic tests were necessary in order to evaluate neurologic disorders; the results of these tests showed significant differences in behavior and memory between the treated Alzheimer’s and Alzheimer’s. A histological study was necessary to confirm the neurologic tests and check the nervous tissues state; our results confirmed the decrease of injuries of the pyramidal cells in the cerebral cortex and hippocampus of treated Alzheimer’s mice.

【 授权许可】

CC BY