Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds

Cumhuriyet Science Journal

article

Göknil COŞKUN¹  Akın AKLAMUZ¹  Ufuk İNCE²  Mert ÜLGEN¹ 

[1] ACIBADEM UNIVERSITY, FACULTY OF PHARMACY;ERCIYES UNIVERSITY, FACULTY OF PHARMACY

关键词: 4-ASA;    Hydrazide;    Hydrazone;    Amide;    Antibacterial activity.;   

DOI  :  10.17776/csj.1105811

学科分类：工程和技术（综合）

来源: Cumhuriyet University

【 摘 要 】

Bacterial infection today occupies a tremendous place in world health. The infection diseases were kept under control after the development of penicillin and further studies were performed on the development of new antibacterial agents. However, to date, bacterial resistance caused a big failure in the treatment of infectious disease and therefore, development of new antibacterial agents became important for human health. In the present study, we have designed, synthesized and elucidated the structures of new hydrazide-hydrazone compounds and their hybrid amide derivatives. The structures of the compounds were elucidated with spectroscopic methods and their purity were proven by TLC, HPLC-MS analysis. The antibacterial and antifungal activity studies of the novel molecules were investigated on different strains. Among the synthesized compounds, AA3a and AA4a appeared to show promising antibacterial activity. None of the compounds showed significant antifungal activity on Candida albicans. The drug likeness properties and boiled-egg plot analysis were performed for all of the compounds. The novel molecules showed no violation on Lipinski’s rule of five and all the molecules showed good gastrointestinal absorption properties in the in silico studies.

【 授权许可】

CC BY-NC-ND