Topical treatments for anal fissure

Canadian family physician: Medecin de famille canadien

article

Callie Fagan¹  Michael R. Kolber²  Adrienne J. Lindblad³ 

[1]Pharmacist at Calgary Co-op in Alberta.

[2]Professor in the Department of Family Medicine at the University of Alberta in Edmonton.

[3]College of Family Physicians of Canada

[4]Department of Family Medicine at the University of Alberta.

DOI  :  10.46747/cfp.690133

学科分类：卫生学

来源: College of Family Physicians of Canada

【 摘 要 】

How effective are topical treatments (calcium channel blockers [CCBs], nitrates, and vitamin E) forchronic anal fissures in adults?Bottom lineHealing rates with topical nitroglycerin are roughly60% versus 40% with placebo at 8 weeks. TopicalCCBs are at least as good as nitroglycerin, with alower risk of headache (7% versus 56%). Based on1 RCT, topical vitamin E may be superior to nitroglycerin (86% versus 66% healed at 8 weeks).

【 授权许可】

CC BY