Bone turnover markers to monitor oral bisphosphonate therapy

Cleveland Clinic journal of medicine

article

Nikita Ashcherkin¹  Archna A. Patel¹  Alicia Algeciras-Schimnich²  Krupa B. Doshi³ 

[1] Department of Medicine, Mayo Clinic;Professor of Laboratory Medicine and Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic;Assistant Professor of Medicine, Division of Endocrinology, Department of Medicine, Mayo Clinic

DOI  :  10.3949/ccjm.90a.22002

学科分类：卫生学

来源: Cleveland Clinic Educational Foundation

【 摘 要 】

Bisphosphonates are widely used as first-line therapy to slow bone loss and decrease fracture risk in postmenopausal women with osteoporosis. Nonadherence to oral bisphosphonates diminishes the benefit of reduced bone loss and fracture risk of these medications. Strategies to enhance osteoporosis monitoring and adherence to therapy are crucial to improve outcomes. Dual-energy x-ray absorptiometry (DXA) is the gold standard for monitoring bone mineral density but is slow to detect change after initiation of oral bisphosphonate therapy. Bone turnover markers (BTMs) are by-products released during bone remodeling and are measurable in blood and urine. We review how the rapid change in BTMs can be a useful short-term tool to monitor the effectiveness of oral bisphosphonate therapy, which may ultimately improve adherence to therapy and outcomes.

【 授权许可】

CC BY