Original research: Degree of loss in the tissue thickness, microvascular density, specific perimetry and standard perimetry in early glaucoma

BMJ Open Ophthalmology

article

Kazunori Hirasawa¹  Jun Yamaguchi¹  Koichi Nagano¹  Junji Kanno²  Masayuki Kasahara¹  Nobuyuki Shoji¹ 

[1]Department of Ophthalmology , Kitasato University School of Medicine

[2]Department of Ophthalmology , Saitama Medical University

关键词: diagnostic tests/investigation;    glaucoma;    imaging;    optic nerve;   

DOI  :  10.1136/bmjophth-2023-001256

学科分类：工业工程学

来源: BMJ Publishing Group

【 摘 要 】

Objective To identify the degree of loss of the circumpapillary retinal nerve fibre layer (cpRNFL), the layer from the macular RNFL to the inner plexiform layer (mGCL++), circumpapillary (cpVD) and macular vascular density (mVD), Pulsar perimetry and standard perimetry in early glaucoma.Methods In this cross-sectional study, one eye from each of 96 healthy controls and 90 eyes with open-angle glaucoma were measured with cpRNFL, mGCL++, cpVD, mVD, Pulsar perimetry with Octopus P32 test (Pulsar) and standard perimetry with Humphrey field analyser 24-2 test (HFA). For direct comparison, all parameters were converted to relative change values adjusted in both their dynamic range and age-corrected normal value.Results The degree of loss in mGCL++ (−24.7%) and cpRNFL (−25.8%) was greater than that in mVD (−17.3%), cpVD (−14.9%), Pulsar (−10.1%) and HFA (−5.9%) (each p<0.01); the degree of loss in mVD and cpVD was greater than that in Pulsar and HFA (each p<0.01); and the degree of loss in Pulsar was greater than that in HFA (p<0.01). The discrimination ability between glaucomatous and healthy eyes (area under the curve) was higher for mGCL++ (0.90) and cpRNFL (0.93) than for mVD (0.78), cpVD (0.78), Pulsar (0.78) and HFA (0.79).Conclusion The degree of loss of cpRNFL and mGCL++ thickness preceded by approximately 7%–10% and 15%–20% compared with the micro-VD and visual fields in early glaucoma, respectively.Trial registration number UMIN Clinical Trials Registry (http://www.umin.ac.jp/; R000046076 UMIN000040372).

【 授权许可】

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