Original research: Risk factors and characteristics of central serous chorioretinopathy with later development of macular neovascularisation detected on OCT angiography: a retrospective multicentre observational study

BMJ Open Ophthalmology

article

Xiaoyin Zhou¹  Yuki Komuku¹  Takashi Araki¹  Hiroto Terasaki²  Akiko Miki²  Soichiro Kuwayama²  Tomo Nishi²  Takamasa Kinoshita²  Fumi Gomi¹ 

[1] Department of Ophthalmology , Hyogo College of Medicine;Japan Clinical Retina Study ,(JCREST) group;Department of Ophthalmology , Kagoshima University;Department of Ophthalmology , Kobe University Graduate School of Medicine;Department of Ophthalmology and Visual Science , Nagoya City University Graduate School of Medical Sciences;Department of Ophthalmology , Nara Medical University;Department of Ophthalmology , Sapporo City General Hospital

关键词: choroid;    macula;    neovascularisation;    retina;   

DOI  :  10.1136/bmjophth-2022-000976

学科分类：工业工程学

来源: BMJ Publishing Group

【 摘 要 】

Objective To identify the risk factors and characteristics of central serous chorioretinopathy (CSC) with subsequent macular neovascularisation (MNV) detected on optical coherence tomography angiography (OCTA).Methods and analysis We included patients from six institutions who were initially diagnosed with CSC and subsequently did or did not develop MNV detected by OCTA. Potential influencing factors were identified by evaluating the patients’ baseline demographics, multimodal fundus imaging, treatment options, recurrence and outcomes in both groups.Results We enrolled 176 eyes in 152 patients (112 men, 40 women; mean age: 52.1±10.4 years) with a mean follow-up of 30.4±16.3 months. Secondary MNV was present in 23 eyes (13.1%), and non-MNV was observed in 153 eyes (86.9%) by OCTA. Multivariate analysis revealed that older age (OR 1.06; 95% CI 1.01 to 1.11; p=0.014), chronic CSC (OR 3.05; 95% CI 1.12 to 8.30; p=0.029), leakage sites within the fovea on fluorescein angiography (OR 7.60; 95% CI, 1.89 to 30.48; p=0.004) and recurrent fluid within the first year (OR 5.12; 95% CI 1.66 to 15.77; p=0.012) were risk factors for subsequent MNV. Moreover, eyes with CSC complicated with MNV were characterised by poor visual acuity and low complete fluid resolution rates.Conclusion The factors associated with MNV secondary to CSC were older age, higher rates of chronic CSC and recurrence, and foveal leakage points on fluorescein angiography.

【 授权许可】

CC BY-NC|CC BY|CC BY-NC-ND