New dual dye for vitreoretinal surgery with increased transparency

BMJ Open Ophthalmology

article

Andreas Mohr¹  Paula Cendoya²  Joanna Wilinska²  Maria Apostu²  Elena Apostu²  Jori Janku²  Tom Wilfling²  Gabriela Ramos²  Mahmoud Al-Joumhawy²  Detlef Gabel² 

[1] Eye Clinic , St Joseph Stift Hospital Bremen;School of Sciences , Jacobs University Bremen gGmbH

关键词: retina;    treatment surgery;   

DOI  :  10.1136/bmjophth-2022-001116

学科分类：工业工程学

来源: BMJ Publishing Group

【 摘 要 】

Objectives To develop a new dye formulation for vitreoretinal surgery, which shows increased transparency for better intraoperative handling with better parameters important for use.Methods and analysis A new blue dye, DDG, was synthesised and tested for toxicity and staining. Diglycerol as new density-increasing additive was identified, and its toxicity and lack of influence of the staining with trypan blue (TB) on a collagen membrane as model for the epiretinal membrane was determined. Transparency of the dye solution was evaluated.Results DDG is as alternative to Brilliant Blue G (BBG), with good staining properties for interna limitans models, and a good safety profile. Diglycerol is a new non-toxic additive replacing PEG3350, with reduced viscosity and no reduction in staining, allowing the reduction of TB to achieve the same staining level of the collagen membrane by 40%, with greater transparency of the dye solution and reduced viscosity. Both factors should facilitate a safe removal during surgery.Conclusion A new dye preparation with improved performance in comparison to marketed combinations of BBG and TB was developed. Its reduced TB concentration and viscosity with maintained density allow better tolerance and handling.

【 授权许可】

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