sTWEAK is a marker of early haematoma growth and leukoaraiosis in intracerebral haemorrhage

Stroke and Vascular Neurology

article

Andrés da Silva-Candal¹  Iria López-Dequidt²  Manuel Rodriguez-Yañez²  Paulo Ávila-Gómez¹  José Manuel Pumar³  José Castillo¹  Tomás Sobrino¹  Francisco Campos¹  Ramón Iglesias-Rey¹  Pablo Hervella¹ 

[1] Clinical Neurosciences Research Laboratory ,(LINC) , Health Research Institute of Santiago de Compostela;Department of Neurology , Hospital Clínico Universitario;Department of Neuroradiology , Hospital Clínico Universitario

关键词: haemorrhage;    vein;    vessel wall;    brain;   

DOI  :  10.1136/svn-2020-000684

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

Objective To study the association between early growth of haematoma with biomarkers of endothelial dysfunction such as leukoaraiosis (LA) and the soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) in patients with intracerebral haemorrhage (ICH).Methods2 at 3 months, was considered as secondary endpoint. Receiver operating characteristic curve analysis was performed to stablish the best cut-off for sTWEAK levels associated with haematoma growth.Results We included 653 patients with ICH in our analysis (71.1±11.9 years, 44% women). Haematoma growth was observed in 188 patients (28.8%). sTWEAK levels ≥5600 pg/mL predicted ICH growth with a sensitivity of 84% and a specificity of 87%. sTWEAK levels ≥5600 pg/mL and the presence of LA were associated with haematoma growth (OR: 42.46; (CI 95% 22.67 to 79.52) and OR: 2.73 (CI 95% 1.39 to 5.34), respectively). Also, the presence of LA (OR: 4.31 (CI 95% 2.89 to 6.42)) and the interaction between ICH growth and sTWEAK (OR: 2.23 (CI 95% 1.40 to 3.55)) were associated with poor functional outcome at 3 months.Conclusion sTWEAKs, together with the presence and grade of LA, are biomarkers able to predict ICH growth and poor functional outcome in patients with ICH.

【 授权许可】

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