Cancer burden in adolescents and young adults in Europe

ESMO Open

article

A. Trama¹  D. Stark²  I. Bozovic-Spasojevic³  N. Gaspar⁴  F. Peccatori⁵  A. Toss⁶  A. Bernasconi¹  P. Quarello⁷  K. Scheinemann⁹  S. Jezdic^1,12  A. Blondeel^1,13  G. Mountzios^1,14  S. Bielack^1,15  E. Saloustros^1,16  A. Ferrari^1,17 

[1] Research Department, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano;Leeds Institute of Medical Research, School of Medicine University of Leeds;Medical Oncology Department, Institute for Oncology and Radiology of Serbia;Department of Oncology for Child and Adolescent, Gustave Roussy Cancer Campus;Gynecologic Oncology Department, European Institute of Oncology IRCCS;Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria di Modena;Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children’s Hospital, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza;University of Torino;Division of Oncology-Hematology, Department of Pediatrics;Department of Health Sciences and Medicine, University of Lucerne, Lucerne;Department of Pediatrics, McMaster Children’s Hospital and McMaster University;Scientific and Medical Division, European Society for Medical Oncology;Department of Scientific Programme Coordination, European Society for Paediatric Oncology;2nd Department of Medical Oncology and Clinical Trial Unit, Henry Dunant Hospital;Zentrum für Kinder, Jugend und Frauenmedizin Pädiatrie 5, Klinikum Stuttgart—Olgahospital;Department of Oncology, University Hospital of Larissa;Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori

关键词: adolescents and young adults;    cancer;    incidence;    mortality;    population-based cancer registry;   

DOI  :  10.1016/j.esmoop.2022.100744

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

Background Cancer epidemiology is unique in adolescents and young adults (AYAs; aged 15-39 years). The European Society for Medical Oncology/European Society for Paediatric Oncology (ESMO/SIOPE) AYA Working Group aims to describe the burden of cancers in AYAs in Europe and across European Union (EU) countries.Patients and methods We used data available on the Global Cancer Observatory. We retrieved crude and age-standardised (World Standard Population) incidence and mortality rates. We reported about AYA cancer burden in Europe and between 28 EU member states. We described incidence and mortality for all cancers and for the 13 cancers most relevant to the AYA population.Results Incidence and mortality varied widely between countries with the highest mortality observed in Eastern EU countries. Cancers of the female breast, thyroid and male testis were the most common cancers across countries followed by melanoma of skin and cancers of the cervix. Variations in cancer incidence rates across different populations may reflect different distribution of risk factors, variations in the implementation or uptake of screening as well as overdiagnosis. AYA cancer mortality disparities may be due to variation in early-stage diagnoses, different public education and awareness of cancer symptoms, different degrees of access or availability of treatment.Conclusions Our results highlight the future health care needs and requirements for AYA-specialised services to ensure a homogeneous treatment across different countries as well as the urgency for preventive initiatives that can mitigate the increasing burden.

【 授权许可】

CC BY|CC BY-NC-ND