Primary tumor side is associated with prognosis of colorectal cancer patients with brain metastases

ESMO Open

article

E.S. Bergen¹  P. Scherleitner¹  P. Ferreira¹  B. Kiesel²  C. Müller³  G. Widhalm²  K. Dieckmann⁴  G. Prager¹  M. Preusser¹  A.S. Berghoff¹ 

[1] Department of Medicine I, Division of Oncology, Medical University of Vienna;Department of Neurosurgery, Medical University of Vienna;Department of Surgery, Medical University of Vienna;Department of Radiooncology, Medical University of Vienna

关键词: colorectal cancer;    brain metastases;    primary tumor side;    sidedness;   

DOI  :  10.1016/j.esmoop.2021.100168

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

Background Brain metastases (BM) are a rare complication in colorectal cancer (CRC) patients and associated with an unfavorable survival prognosis. Primary tumor side (PTS) was shown to act as a prognostic and predictive biomarker in several trials including metastatic CRC (mCRC) patients. Here, we aim to investigate whether PTS is also associated with the outcome of CRC patients with BM.Methods Patients treated for CRC BM between 1988 and 2017 at an academic care center were included. Right-sided CRC was defined as located in the appendix, cecum and ascending colon and left-sided CRC was defined as located in the descending colon, sigma and rectum.Results Two hundred and eighty-one CRC BM patients were available for this analysis with 239/281 patients (85.1%) presenting with a left-sided and 42/281 patients (14.9%) with a right-sided primary CRC. BM-free survival (BMFS) was significantly longer in left-sided compared with right-sided CRC patients (33 versus 20 months, P = 0.009). Overall survival from CRC diagnosis as well as from diagnosis of BM was significantly longer in patients with a left-sided primary (42 versus 25 months, P = 0.002 and 5 versus 4 months, P = 0.005, respectively). In a multivariate analysis including graded prognostic assessment, PTS remained significantly associated with prognosis after BM (hazard ratio 0.65; 95% confidence interval: 0.46-0.92 months, P = 0.0016).Conclusions PTS was associated with survival times after the rare event of BM development in CRC patients. Therefore, its prognostic value remains significant even thereafter.

【 授权许可】

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