Adolescents and young adults (AYA) with cancer: a position paper from the AYA Working Group of the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE)

ESMO Open

article

A. Ferrari¹  D. Stark²  F.A. Peccatori³  L. Fern⁴  V. Laurence⁵  N. Gaspar⁶  I. Bozovic-Spasojevic⁷  O. Smith⁸  J. De Munter⁹  K. Derwich^1,10  L. Hjorth^1,11  W.T.A. van der Graaf^1,12  L. Soanes^1,13  S. Jezdic^1,14  A. Blondeel^1,15  S. Bielack^1,16  J.-Y. Douillard^1,14  G. Mountzios^1,17  E. Saloustros^1,18 

[1] Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori;Leeds Institute of Medical Research, School of Medicine University of Leeds;Gynecologic Oncology Department, European Institute of Oncology IRCCS;Department of Oncology, University College London Hospitals NHS Foundation Trust;Medical Oncology Department and SIREDO Oncology Center ,(Care, Innovation and Research for Children and AYA with Cancer), Institut Curie;Department of Oncology for Child and Adolescent, Gustave Roussy Cancer Campus;Medical Oncology Department, Institute for Oncology and Radiology of Serbia;National Children"s Cancer Service, Children"s Health Ireland at Crumlin and Systems Biology Ireland, University College Dublin;University Hospital Ghent Cancer Center;Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences;Lund University, Skane University Hospital, Department of Clinical Sciences Lund;Department of Medical Oncology, The Netherlands Cancer Institute;Teenage Cancer Trust;Scientific and Medical Division, European Society for Medical Oncology;Department of Scientific Programme Coordination, European Society for Paediatric Oncology;Zentrum für Kinder, Jugend und Frauenmedizin Pädiatrie 5, KlinikumStuttgart – Olgahospital;2nd Department of Medical Oncology and Clinical Trial Unit, Henry Dunant Hospital;Department of Oncology, University Hospital of Larissa

关键词: adolescents and young adults;    cancer;    clinical trials;    education;    interdisciplinary;   

DOI  :  10.1016/j.esmoop.2021.100096

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

It is well recognised that adolescents and young adults (AYA) with cancer have inequitable access to oncology services that provide expert cancer care and consider their unique needs. Subsequently, survival gains in this patient population have improved only modestly compared with older adults and children with cancer. In 2015, the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE) established the joint Cancer in AYA Working Group in order to increase awareness among adult and paediatric oncology communities, enhance knowledge on specific issues in AYA and ultimately improve the standard of care for AYA with cancer across Europe. This manuscript reflects the position of this working group regarding current AYA cancer care, the challenges to be addressed and possible solutions. Key challenges include the lack of specific biological understanding of AYA cancers, the lack of access to specialised centres with age-appropriate multidisciplinary care and the lack of available clinical trials with novel therapeutics. Key recommendations include diversifying interprofessional cooperation in AYA care and specific measures to improve trial accrual, including centralising care where that is the best means to achieve trial accrual. This defines a common vision that can lead to improved outcomes for AYA with cancer in Europe.

【 授权许可】

CC BY|CC BY-NC-ND