ESMO Open | |
Small-cell lung cancer in never-smokers | |
article | |
M. Torres-Durán1  M.T. Curiel-García2  A. Ruano-Ravina3  M. Provencio6  I. Parente-Lamelas7  J. Hernández-Hernández8  A. Fernández-Villar1  J.M. Barros-Dios3  M. Pérez-Ríos3  | |
[1] Service of Neumology, University Hospital Complex of Vigo;Department of Medical Oncology, Hospital HM La Esperanza;Department of Preventive Medicine and Public Health, University of Santiago de Compostela;Consortium for Biomedical Research in Epidemiology and Public Health;Instituto de Investigaciones Sanitarias de Santiago de Compostela;Service of Medical Oncology, Puerta de Hierro University Hospital of Madrid;Service of Neumology, University Hospital Complex of Ourense;Service of Neumology | |
关键词: small-cell lung cancer; residential radon; never-smokers; survival; | |
DOI : 10.1016/j.esmoop.2021.100059 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: BMJ Publishing Group | |
【 摘 要 】
Background Lung cancer is a public health problem worldwide. Small-cell lung cancer (SCLC) is the most aggressive histologic type, with a 5-year survival <10%. SCLC is closely associated with tobacco consumption and infrequent in never-smokers. We aim to describe SCLC characteristics in never-smokers recruited in a radon-prone area.Patients and methods We designed a multicentric case series where SCLC cases were recruited consecutively following histologic confirmation. Detailed information was obtained for indoor radon exposure, occupation and environmental tobacco smoke. We also collected different clinical characteristics such as extended or limited disease at diagnosis.Results We recruited 32 never-smoking SCLC cases. Median age was 75 years and 87.5% were women; 47% had extended disease. Median radon concentration was 182 Bq/m3. There were no statistically significant differences in residential radon concentration neither regarding age at diagnosis nor regarding sex. The most frequent symptoms were constitutional syndrome (23.1%) and coughing (23.1%). As much as 63% of cases had an Eastern Cooperative Oncology Group Study (ECOG) status of 0-2. The 1- and 2-year survival rates were 34.4% and 21.9%, respectively. The 2-year survival rate with a localized tumor was 26.7%, compared with 18.8% for extended disease.Conclusions These results show, for the first time, that indoor radon might not be associated with SCLC characteristics at diagnosis in never-smokers, and also confirms the low survival of this aggressive type of lung cancer also for never-smokers.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
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