期刊论文详细信息
Biocell
Co-regulator NCOA5 and cancer
article
YUANYUAN CHEN1  SHUAISHUAI CUI1  YUNFEI GUO1  DAHU CHEN1 
[1] School of Life Sciences, Shandong University of Technology
关键词: NCOA5;    Co-regulator;    Structure and function;    Nuclear receptors;    Cancer;   
DOI  :  10.32604/biocell.2022.019142
学科分类:仪器
来源: Biocell
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【 摘 要 】

NCOA5 encodes a co-regulator for estrogen receptors (ERα and ERβ), orphan nuclear receptors (REV-ERBαand REV-ERBβ) and liver X receptor. It can influence many cellular processes by either promoting or inhibiting geneexpression through its two important functional motifs: LxxLL (co-activator) and ΦxxΦΦ (co-repressor). Manyreports have revealed the important roles of NCOA5 in diseases, such as diabetes, reproductive defects andautoimmune disease. In this review, we focus on its function in cancers and summary the current research progressesregarding its different roles in various cancers.

【 授权许可】

CC BY   

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