ER exit pathways and the control of proteostasis: Crucial role of the UPR, COPII, and ER-phagy in the secretory pathway

Biocell

article

GIUSEPPINA AMODIO¹  VALENTINA PAGLIARA¹  PAOLO REMONDELLI¹  ORNELLA MOLTEDO² 

[1] Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”, Università degli Studi di Salerno;Dipartimento di Farmacia, Università degli Studi di Salerno

关键词: Proteostasis;    ER stress;    Unfolded protein response;    COPII;    ER-phagy;   

DOI  :  10.32604/biocell.2022.018638

学科分类：仪器

来源: Biocell

【 摘 要 】

The endoplasmic reticulum (ER) is the site of entry of all proteins that function in the secretory pathway including the extracellular environment. Because it controls the folding of newly synthesized secretory proteins, the ER is indispensable for the maintenance of proteostasis in the secretory pathway. Within the ER and, in part, in post-ER compartments, the quality control of protein folding is under the regulation of the unfolded protein response (UPR) pathways. The UPR strategy is to enhance protein folding, increase the ER degradation pathway of misfolded proteins, and allow the exit from the ER of only correctly folded proteins. The latter is controlled by the multimeric complex COPII, which also provides some of the components for ER-phagy the only route for the disposal of protein aggregates. In this overview, we wish to contribute to the introduction of new perspectives in the study of the mechanisms underlying the control of proteostasis within the secretory pathway.

【 授权许可】

CC BY