The Evaluation of Intestinal Permeability in Preeclamptic Pregnancy

Materia Socio Medica

article

Gulsen Mutluoglu¹  Tugba Yay²  Aycan Boluk Gülsever³  Ozlem Cakir Madenci³ 

[1]Department of Laboratory Medicine, General Hospital Groeninge

[2]Department of Obstetrics and Gynecology, Umraniye Training and Research Hospital

[3]Department of Biochemistry, Dr. Lütfi Kirdar Education and Training Hospital

关键词: preeclampsia;    intestinal permeability;    zonulin;    lipopolysaccharide binding protein;    IL-2 receptor.;   

DOI  :  10.5455/msm.2023.35.48-52

学科分类：社会科学、人文和艺术（综合）

来源: Avicena d.o.o

【 摘 要 】

Background: Zonulin is a physiological protein that regulates the tight connections and permeability of the intestine, serving as a biomarker for impaired intestinal permeability. Objective: The aim of this study was to examine zonulin levels in preeclampsia, to investigate its associations with the cellular immune response marker soluble interleukin-2 receptor (sIL-2R) and exogenous antigen load marker lipopolysaccharide binding protein (LBP) and to evaluate the implications of these findings in the etiopathogenesis of preeclampsia. Methods: We designed a cross-sectional case-control study and enrolled 22 pregnant women with preeclampsia and 22 healthy pregnant controls. Plasma zonulin levels were determined by ELISA. Serum sIL-2R and LBP levels were assessed by chemiluminescent immunometric methods.

【 授权许可】

CC BY