Hyperleptinemia as a risk factor for post-transplant diabetes mellitus development after kidney transplantation

Bratislava Medical Journal

article

Karol GRANAK¹  VNUCAK Matej¹  Monika BELIANCINOVA¹  Margareta PYTLIAKOVA³  Ivana DEDINSKA¹ 

[1] Transplant Centre, University Hospital Martin, Jessenius Medical Faculty of Comenius University;Clinic of Internal Medicine I, Jessenius Medical Faculty of Comenius University;Clinic of Gastrointestinal Internal Medicine, University Hospital Martin, Jessenius Medical Faculty of Comenius University

关键词: adipocytokines;    interleukins;    post-transplant diabetes mellitus;    kidney transplantation;    leptin;   

DOI  :  10.4149/BLL_2022_092

学科分类：医学（综合）

来源: AEPress, s.r.o.

【 摘 要 】

INTRODUCTION: Adipose tissue is involved in the synthesis of hormones that have an impact on food intake regulation, control of insulin sensitivity or regulation of inflammatory processes. The aim of this study was to determine the importance of adipocytokines and interleukins levels for the development of post-transplant diabetes mellitus (PTDM) after kidney transplantation (KT).MATERIAL AND METHODS: In the prospective analysis, the studied sample (n = 104) was divided into the control group, prediabetes group and PTDM group. Prior to transplantation, and subsequently, at 3, 6 and 12 months after KT, we recorded the basic characteristics of the donor and recipient, including parameters reflecting graft function, metabolic and anthropometric parameters. At the same time, we monitored the levels of adiponectin, leptin and interleukins during the monitored period.RESULTS: Using multivariate logistic regression, we identified hyperleptinemia 12 months after KT as an independent risk factor for PTDM development 1 year after KT [OR 1.0320; 95% Cl 0.9785–1.0884 (p=0.0038)]. At the same time, we confirmed that age at the time of KT is also an independent risk factor for PTDM [OR 1.0903; 95% Cl 1.0149–1.1714 (p=0.0180)]. CONCLUSION: We confirmed that elevated leptin level 12 months after KT is associated with the development of PTDM (Tab. 3, Fig. 4, Ref. 22).

【 授权许可】

CC BY