17 beta-estradiol decreases endothelin-l levels in the coronary circulation of postmenopausal women with coronary artery disease

Article

关键词: INDUCED MYOCARDIAL-ISCHEMIA;    NITRIC-OXIDE SYNTHASE;    HEART-DISEASE;    SUBSTANCE-P;    ESTROGEN-RECEPTOR;    CELLS;    ACETYLCHOLINE;    ESTRADIOL;    RESPONSES;    PLASMA;   

DOI  :  10.1161/01.CIR.102.14.1617

来源: SCIE

【 摘 要 】

Background-Estrogen reverses acetylcholine-induced coronary vasoconstriction via the possible facilitation of endothelium-derived NO. Estrogen also affects endothelium-derived constrictor factors. We therefore investigated the effects of 17 beta-estradiol on coronary vasomotor responses to substance P (SP), and coronary sinus endothelin-1 and NO metabolite levels in postmenopausal women with coronary heart disease. Methods and Results-We studied 20 women, 14 received estrogen (mean age 65+/-2 years) and 6 served as ethanol control subjects (age 63+/-3 years). Intracoronary infusions of papaverine (8 mg) and SP were administered before and 20 minutes after 50 pg/min 17 beta-estradiol or 0.2 mu L/min control. Coronary blood flow was calculated from the diameter, as measured with quantitative coronary angiography, and flow velocity, as measured with intracoronary Doppler. Coronary sinus plasma endothelin-l and nitrite/nitrate (NO2/NO3) were measured at baseline, at peak velocity response to each infusion, and every 5 minutes during the estradiol infusion. Endothelin-l levels were decreased after 20 minutes of estradiol (1.12+/-0.18 versus 0.86+/-0.17 pmol/L baseline2 versus estradiol, P=0.05). Endothelin-1 levels to SP decreased after 17 beta-estradiol (1.29+/-0.18 versus 1.04+/-0.15 and 1.3+/-0.16 versus 0.99+/-0.17 pmol/L for before versus after estradiol, 10 and 25 pmol/min SP; both P<0.05). NO2/NO3 levels did not change. There was no change in vasomotor responses to estradiol alone or to papaverine or SP before versus after estradiol. Conclusions-Short-term intracoronary 17 beta-estradiol administration decreases coronary endothelin-1 levels. There was no enhancement of vasomotor responses to SP after the administration of estrogen, suggesting that the effects of estrogen on coronary acetylcholine responses may be a specific and not a generalized effect on coronary vasoreactivity.

【 授权许可】

Free