Prevalence and prognostic significance of short QT interval in a middle-aged Finnish population

Article

关键词: CORONARY-HEART-DISEASE;    HEALTHY-PERSONS;    SUDDEN-DEATH;    MORTALITY;    ELECTROCARDIOGRAMS;    EXPERIENCE;    RISK;   

DOI  :  10.1161/CIRCULATIONAHA.106.676551

来源: SCIE

【 摘 要 】

Background - Short- QT syndrome is an inherited disorder characterized by a short QT interval and an increased risk of sudden cardiac death. The clinical significance of a short QT interval observed in a randomly recorded ECG is not known. Therefore, we assessed the prevalence and prognostic significance of a short QT interval in a general population. Methods and Results - QT intervals were measured from the 12- lead ECGs of 10 822 randomly selected middle- aged subjects ( 5658 males, mean age 44 +/- 8.4 years) enrolled in a population study and followed up for 29 +/- 10 years. The end points were all- cause and cardiovascular mortality. In addition to Bazett's method ( corrected QT interval, or QTc), the Fridericia ( QTfc) and nomogram ( QTnc) methods were used to correct the QT interval for heart rate. The cutoff values for short QT intervals were defined as 320 ms ( very short) and 340 ms ( short). The prevalence of QT interval < 320 ms based on QTc, QTfc, and QTnc was 0.10%, 0.08%, and 0.06%, and the prevalence of QT interval < 340 ms was 0.4%, 0.3%, and 0.3%, respectively. The majority of subjects with short QT intervals were males. All- cause or cardiovascular mortality did not differ between subjects with a very short or short QT interval and those with normal QT intervals ( 360 to 450 ms). There were no sudden cardiac deaths, aborted sudden cardiac deaths, or documented ventricular tachyarrhythmias among subjects with a QTfc < 340 ms. Conclusion - A short QT interval does not appear to indicate an increased risk for all- cause or cardiovascular mortality in middle- aged nonreferral, community- based individuals.

【 授权许可】

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