Right Ventricular Systolic Dysfunction in Young Adults Born Preterm

Article

关键词: CARDIOVASCULAR MAGNETIC-RESONANCE;    PRIMARY PULMONARY-HYPERTENSION;    RIGHT-HEART-FAILURE;    LOW-BIRTH-WEIGHT;    MECHANICAL VENTILATION;    MOLECULAR-MECHANISMS;    ENDOTHELIAL FUNCTION;    CARDIAC-FUNCTION;    BLOOD-PRESSURE;    DISEASE;   

DOI  :  10.1161/CIRCULATIONAHA.113.002583

来源: SCIE

【 摘 要 】

Background-Young adults born preterm have distinct differences in left ventricular mass, function, and geometry. Animal studies suggest that cardiomyocyte changes are evident in both ventricles after preterm birth; therefore, we investigated whether these young adults also have differences in their right ventricular structure and function. Methods and Results-We studied 102 preterm-born young adults followed up prospectively since birth and 132 term-born control subjects born to uncomplicated pregnancies. We quantified right ventricular structure and function by cardiovascular magnetic resonance on a 1.5-T Siemens scanner using Argus and TomTec postprocessing software. Preterm birth was associated with a small right ventricle (end diastolic volume, 79.8 +/- 13.2 versus 88.5 +/- 11.8 mL/m(2); P<0.001) but greater right ventricular mass (24.5 +/- 3.5 versus 20.4 +/- 3.4 g/m(2); P<0.001) compared with term-born controls, with the severity of differences proportional to gestational age (r=-0.47, P<0.001). Differences in right ventricular mass and function were proportionally greater than previously reported for the left ventricle. This was most apparent for systolic function; young adults born preterm had significantly lower right ventricular ejection fraction (57 +/- 8% versus 60 +/- 5%; P=0.006). Indeed, 21% had values below the lower limit observed in the term-born adults and 6% had mild systolic dysfunction (<45%). Postnatal ventilation accounted for some of the variation in mass but not function. Conclusions-Preterm birth is associated with global myocardial structural and functional differences in adult life, including smaller right ventricular size and greater mass. The changes are greater in the right ventricle than previously observed in the left ventricle, with potentially clinically significant impairment in right ventricular systolic function.

【 授权许可】

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